Hemispheric University

Universidad Andrés Bello

Research Project Title

Thermostable Botrycide

Research Project Description

Technical summary: The technology comprises an enriched thermostable metabolite extract from the fungus Chaetomium globosum and the methodology to produce it. The extract is enriched with three metabolites, called M1, M2 and M3, and have the capability to control Botrytis cinerea growing in fruits and related products. The extract is able to inhibit up to 80% the mycelial growing of B. cinerea in in vitro assays. Also, it can inhibit the germination of conidia from 20% to 95%. In table grape bioassays, it was shown a reduction of the B. cinerea incidence of 50% to 76%, depending on the grape variety.


Potential impact of the use of the technology: This technology represents a new biological tool to control Botrytis infections, with a high botrycide efficacy based on different action mechanisms against Botrytis-caused rotting. Also, this technology could help to reduce the use of chemical fungicides which have several limitations in terms of ecological impact and exportation. It is estimated than Chilean fruits with a fungicide with the present metabolite extract could have a 50% less rejections in terms of exportation, compared to those fruits which use chemical fungicides, which is equivalent to US$ 100 million (calculated for table grapes, blueberries, cherries, wine grapes, and tomatoes).


Market: The objective market in Chile for a thermostable fungicide corresponds to retailer distributors who sell fungicide and other agrochemical products. In Chile, the main Botrytis-affected regions are Coquimbo and El Maule. Companies which operates in these affected regions are Coopeval, Coagra, Cals, FEROSOR, among others. The estimated national market in 2017 was about US$ 90 million, considering different products, like agrochemical products, biopesticides and biostimulants. This way, the market for Botrytiscaused rotting in Chile is disaggregated as it follows: US$ 83 million in agrochemical products (used in table grapes, USD$ 43 million; cherries, US$ 24 million; wine grapes, US$ 7 million; blueberris, US$ 4 million; tomatoes, US$ 2,5 million; and other species, US$ 3 million), and US$ 7 million in biopesticides and biostimulants. 


Development status: TRL 3: In vitro activity and efficacy demonstrated.

Research Project Academic Contact

Ruben Polanco, Biosciences School Director